amino acid starvation - 2023 Chicago Open

Question

Description acceptable. Both the ISR pathway and a pathway triggered in response to this more specific condition are triggered by the alkaloid halofuginone. Pediatric A·L·L is most commonly treated using a combination of vincristine, a steroid, and a drug that induces this condition. The enzyme Rel·A is activated when it recognizes an unligated molecule whose presence indicates this condition. The protein GCN2 (15[1])is named for a “general control” pathway triggered by this condition, and triggers the deactivation of (*) m·TOR. In bacteria and plants, this is the primary condition that triggers the production of the alarmone guanosine pentaphosphate, (10[1])which (-5[1])activates the stringent response. Cells experiencing this type (10[1])of cellular stress typically have increased amounts of uncharged t·RNAs (-5[1])and may undergo ribosome stalling. For 10 points, name this cellular stress caused (-5[1])by a lack of molecules that comprise (-5[1])polypeptides. (10[1])■END■ (10[4]0[2])

ANSWER: amino acid starvation [accept answers that describe a lack of amino acids; accept answers that describe a lack of specific amino acids like asparagine deficiency; prompt on cellular stress; prompt on starvation or nutrient starvation by asking “starvation of what?”]

= Average correct buzz position

Conv. %	Power %	Average Buzz
89%	11%	118.25

Back to tossups

Buzzes

Player	Team	Opponent	Buzz Position	Value
Vishwa Shanmugam	In Search of Things Past	BHSU	61	15
Andrew Wang	The anti-STOON-dahl cabal (the tall Keyal et al.)	[moderator voice] yes that is so tenpointscore! is your team feeling bonuspilled?	96	10
Eric Mukherjee	Curse you, Periplus the Platypus!	Hang et al., Robert Browning	97	-5
Kevin Wang	I would prefer not to	remembrance of lost time	105	10
Chris Ray	Teach Us to Outgrow Our Ladness	Evans Hall destruction awaiters	115	-5
Cyrus Zhou	wave2: trimming membership codes 9655377758gp	Saint Peter Andre 3000	128	-5
Raul Passement	Romanos IV Diogenes’ Macaroni Grill	The Catastrophic Implosion of Packet Sub	135	-5
Shahar Schwartz	Saint Peter Andre 3000	wave2: trimming membership codes 9655377758gp	136	10
Kevin Ye	Evans Hall destruction awaiters	Teach Us to Outgrow Our Ladness	137	10
Charles Hang	Hang et al., Robert Browning	Curse you, Periplus the Platypus!	137	0
Mike Sorice	Team Name Think Detail	Quasicrystal Silence	137	0
Vittal Bhat	Quasicrystal Silence	Team Name Think Detail	137	10
Mazin Omer	Don't be Afraid, the Clown's Afraid Too	The Canadians	137	10
Nick Jensen	The Catastrophic Implosion of Packet Sub	Romanos IV Diogenes’ Macaroni Grill	137	10