Question
Nucleoside phosphonates named for this property are an important class of antivirals. For 10 points each:
[10h] Give this property that appears in the name of an antiviral medication that competitively inhibits guanosine. The second Green–Davies–Mingos rule states that nucleophiles preferentially attack compounds with this property.
ANSWER: acyclic [or open-chain; accept Aciclovir; accept acyclic nucleoside phosphonates; accept answers indicating no ring; prompt on ANPs] (Aciclovir contains a ring, but its name is a portmanteau of “acyclic” and “viral DNA.”)
[10e] The first Green–Davies–Mingos rule states that nucleophilic attack preferentially occurs on ligands with an even value for this quantity, symbolized eta. This quantity is the number of contiguous atoms on a ligand that bind to the metal center.
ANSWER: hapticity
[10m] Reactions that rely on nucleophilic addition to polyenes include this reaction, in which palladium(II) (“palladium two”) chloride and copper(II) (“copper two”) chloride catalyze the oxidation of ethylene to acetaldehyde.
ANSWER: Wacker process [or Wacker oxidation]
<EM/KP, Chemistry>
Data
Summary
| Tournament | Edition | Exact Match? | Heard | PPB | Easy % | Medium % | Hard % |
|---|---|---|---|---|---|---|---|
| 2024 Chicago Open | 07/28/2024 | Y | 9 | 12.22 | 89% | 33% | 0% |