Question

The J-domain of a protein from this virus is critical for fibroblast cell lines to overcome p130/p107 repression and mediates binding with Hsc70. Carboxy-terminal residues on a protein from this virus redundantly control its binding to the innate inhibitor of WAF-1. Since that protein from this virus binds importin-alpha, it is used as a model protein to study nuclear localization signals. (15[1])Residues 106 to 114 on a protein from this virus contain a key L-X-C-X-E motif that regulates its binding to (*) retinoblastoma protein. The malignant transforming activity (-5[1])of that (-5[1])helicase from this virus has led to its usage in lentiviral cell immortalization kits since it inactivates p53. In the 1950s, this virus was identified as a contaminant in multiple polio vaccines. For 10 points, name this polyomavirus whose namesake large T antigen was first collected from a culture (-5[1])of (10[1])infected monkey (10[1])kidney (-5[1])cells. (0[1]) (10[1]0[10])■END■

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